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Mentor(s): Rock Mancini, Ph.D., and S M Al Muied Pranto

The Mancini Research Lab is focused on synthesizing immunotherapeutic glycoconjugates, polymers and determining the in vitro and in-vivo efficacy of these drugs. In this study, we are working on determining in-vivo efficacy of BAIT-628 in a MDR prostate model. Our research question which is ‘Does Bait-628 have an immunogenic effect against MDR prostate cancer in-vivo?’ We hypothesized that BAIT-628 will have improved efficacy on MDR prostate cancer than treatment naïve prostate cancer. With that being said, our approach was to do multiple experiment tests with culturing a prostate cancer cell line, and making it resistant to 1 Micromolar Doxorubicin. Upon resistance, we are to inject those MDR prostate cancer in C57BL-6 mice. Following the tumor growth, BAIT-628 drug will be injected into MDR tumors.  Afterwards, we will  determine if there is an efficacy of BAIT-628 by tumor growth delay study. Our future plan is to determine the tumor histology and immuno-histochemical analysis of immune cell subsets. Overall this is relevant for my intended career because I personally want to work in the medical field and with this study I am able to work with cancer cells which gives me the ability to study them in-depth.